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What Is the DifferenceBetween Rejuran and Juvelook?
In brief
- Ingredient Difference
- Rejuran is based on PN; Juvelook is based on PDLLA and hyaluronic acid.
- Selection Criteria
- Distinguish between skin texture/fine lines and depressions/cheek hollowing.
- What to Compare
- Compare product names, treatment areas, number of sessions, and recovery needs together.
Explore this article
“My skin texture is rough and my pores are visible. Which should I choose between Rejuran and Juvelook?”
Rejuran and Juvelook are distinct product lines — Rejuran uses PN, while Juvelook uses PDLLA particles and hyaluronic acid. Both come up in consultations about skin texture and fine lines. That said, if hollowing in the cheeks is your main concern, it helps to separate skin texture improvement from volume correction. Let's compare them in order: ingredients, your concerns, and recovery demands.
What Is the Difference Between Rejuran and Juvelook?
Rejuran uses an ingredient called PN; Juvelook uses PDLLA particles and hyaluronic acid. Studies on PN have examined changes in skin texture and fine lines, while research on PDLLA and hyaluronic acid has looked at skin changes and collagen increases, among other things. The ingredients differ, but the concerns they address do overlap — so it's hard to draw a clean line like "dryness always means Rejuran, pores always mean Juvelook."
| Criterion | Rejuran | Juvelook |
|---|---|---|
| Ingredient | PNpolynucleotide | PDLLA + HApoly-D,L-lactic acid and hyaluronic acid |
| Consultation Goals | Skin condition such as skin texture and fine lines | Skin texture and fine lines, etc.Depressions and volume are addressed with separate product and plan distinctions |
| Product Selection | Specific formulations and doses suited to the area | Product specifications such as standard and volume, and areas of use |
| Recovery Burden | Injection marks, bruising, swelling, pain | Injection marks, bruising, swelling, painAlso check for firm lumps that persist over time |
This table does not determine superiority of products or individual suitability. Formulations and treatment plans differ even within the same brand.
If both treatments are described only as ‘injections that improve skin,’ it becomes difficult to choose. This is because changes to the skin surface and three-dimensional volumetric changes to the face are different goals. The starting point of consultation also differs depending on whether you want the skin surface to become smoother, or whether you want to address hollowing that creates shadows.
After the product name, look at which area is being treated and what specifically you want to change. Even within the same brand, the comparison changes if the actual product used or the injection plan is different.
What Is Your Main Concern — Skin Texture, Pores, or Cheek Hollowing?
Start with the one thing you most want to change when you look in the mirror. Tightness after cleansing, pores where makeup settles, and hollowing along the cheeks are three different concerns. Even when several issues are present at once, setting priorities makes it easier to understand why a particular treatment is being recommended.
| Concern | What to Distinguish | Questions to Ask |
|---|---|---|
| Dryness · Fine Lines | Tightness, flaking, areas of wrinkles, presence of irritation or inflammation | Are you addressing tightness or fine lines?Also check whether skin irritation or inflammation should come first |
| Pores · Depressed Scars | Whether it is pores or scarring, depth and shape of depressions | Is injection alone enough for this depression?Ask why additional scar treatments are being recommended |
| Cheek · Temple Hollowing | Skin surface versus actual volume deficit | Is this product for volume rather than skin texture?Confirm which specific formulation — standard, volume, etc. — will actually be used |
If Dryness and Fine Lines Are a Concern
Identify which bothers you most: tightness after cleansing, makeup settling into lines, or fine lines around the eyes. Skin injection treatments may be discussed, but if you have recurring stinging, redness, or flaking, an assessment for irritation and skin conditions may be needed first. Fine lines around the eyes and rough texture across the entire cheek are not grouped as the same problem.
If Pores and Acne Scars Are Both Visible
Pores that appear as small dots and depressed scars must be distinguished. Treatment plans also differ depending on whether scars are narrow and deep, wide and shallow, or appear to be pulled downward. If an injection treatment is recommended, it is good to receive an explanation of which type of depression it addresses and which areas may require other treatments.
The distinction of Rejuran for dryness only and Juvelook for pores only is also insufficient. PN research also includes pore-related indicators. However, results from research showing improvement in skin indicators cannot be read as meaning that all forms of scarring will improve.
If the Shadow on the Side of the Cheek Is a Concern
In this case, volume rather than texture may be the primary concern. Even if the skin surface becomes smoother, if the shadow in the hollow area remains, the result may feel different from what you wanted. Identify the area you are most bothered by in the same photo, and distinguish whether the plan addresses the surface or compensates for volume.
Smoother skin and less hollow cheeks are two different outcomes. Deciding which change matters most to you also clarifies the criteria for choosing a product.
Are Juvelook and Juvelook Volume the Same Product?
They are not the same product. "Volume" in the name does not mean a superior grade. The formulation and intended use differ. Whether you want to refine skin texture or correct three-dimensional hollowing should guide which product is actually used.
The manufacturer’s product information lists different specifications such as Juvelook 50mg, Juvelook Volume 200mg, and Volume100. If you compare prices based on the name alone in a plan targeting skin texture versus one targeting three-dimensional volume enhancement, it is easy to miss the actual conditions.
With Rejuran as well, it is difficult to know whether it is the same treatment based on the brand name and cc alone. The specific formulation to be used, the area, and the dose must all be considered together. The information needed for comparison is not the expression ‘the stronger product,’ but rather the exact product name, area of use, and expected change.
The intended use of Juvelook as disclosed by the manufacturer is the temporary improvement of facial wrinkles in adults. Research on pores, scars, and similar topics, or explanations given during consultations, should not all be understood as officially approved indications. Please ask to have the proposed use and the approved scope of the actual product explained separately.
When Will I See Results, and How Many Sessions Are Needed?
The fullness you see on the day of treatment is not the final result — assess skin changes over several weeks. How many sessions you need and how far apart they should be depends on the product, the area, and how your skin recovers. If you don't look different the next day, that is not grounds to call it a failure or to increase the amount right away.
Immediately after the procedure, the effects of the injected material and swelling are mixed together. If you interpret that appearance as entirely the result of new collagen being formed, it is easy to feel that the effect has disappeared as the swelling subsides. It is better to compare fine lines around the eyes using the same expression, and cheek skin texture under the same lighting.
- After the First SessionObserve how pain, bruising, and injection marks decrease. Do not increase the dose for the next session based on the day-of feeling alone.
- Before the Next SessionEvaluate remaining discomfort and the targeted change together. If there are lumps or suspected signs of inflammation, postpone additional injections and seek medical care.
- After the Planned CourseCompare with photos taken before the start. If satisfaction is low, rather than simply increasing the number of sessions, revisit the goals and treatment choices.
Even in published research, multi-session plans were used, but those schedules are not recommended intervals for everyone. The specific research conditions are summarized at the end of this article. Maintenance treatments are also discussed based on the changes that remain and the concerns to be addressed again, along with how much time has passed.
Along with the number of sessions, agree on when you will compare results. Before each follow-up, review both what has improved and what discomfort remains.
How Much Attention Should Be Paid to Pain and Embossing?
Both treatments can cause injection marks, bruising, swelling, and discomfort. It is difficult to say that one product is always less painful or heals faster than the other. Whether the area is around the eyes or the cheeks, how large the treatment area is, and the injection and anesthesia method all play a role.
The small raised dots that appear at shallow injection sites right after treatment are commonly called "embossing." These are different from nodules — firm lumps that persist over time. Watch to see whether the marks fade, and do not dismiss a lump that lingers or appears later as just part of normal recovery.
| Change | What to Watch | What to Do |
|---|---|---|
| Injection Marks · Bruising | Whether range and discomfort are decreasing | Follow the post-care instructions givenAllow recovery time around photo and in-person appointments |
| Persistent Firm Lumps | Firmness, pain, newly formed lumps | Contact the clinic where treatment was performedDo not press or massage directly |
| Worsening Redness · Heat | Increasing pain, re-expanding swelling | Seek medical care promptlyDo not wait until the next session |
This table does not establish the cause based on symptoms alone. If unexpected changes occur, a medical professional must evaluate based on the actual product and treatment area.
The fact that Juvelook contains hyaluronic acid does not mean the entire product can be dissolved as easily as a standard HA filler. PDLLA is a separate component. When a nodule is suspected, do not follow another person’s massage method or medication; seek medical care to identify the cause first.
If you have important appointments, please mention your work schedule and photography dates specifically. The burden differs between a day with a video conference and a shoot requiring heavy makeup. If you have had prolonged bruising from previous injection treatments, factor that experience into the schedule as well.
Being able to go to work is not the same as having no visible marks. Allow extra time before any important engagements, and contact the clinic right away if a mark becomes red and painful instead of fading.
Is It Better to Receive Both Together?
Receiving both treatments together is not a requirement. Combining them makes sense when each addresses a genuinely different concern — for example, fine lines around the eyes and depressions in the cheeks. If both are being recommended for the same concern, ask what role each one plays before proceeding.
For example, if the plan is to address fine lines around the eyes and depressions on the cheek separately, the goals can be divided by area. If the goal is a vague overall facial glow, rather than layering multiple types from the start, there is also the option of first discussing the necessity and response to one plan.
Separating the sequence can help identify after which treatment a change or discomfort occurred. Doing them on the same day can reduce the number of visits, but the recovery needs and cost must be considered together. Receiving them on the same day and mixing them in the same syringe are different methods, so do not assume based on the word ‘combined’ alone.
Start by asking what the second treatment adds that the first does not. It is also an option to observe how your skin responds to one treatment first and then decide on the order from there.
How Should Prices Be Compared?
Confirm that the product, formulation, and area are the same before comparing total costs. A lower price per cc may still mean a different concentration or a different scope of coverage on the face. Looking only at the per-session cost makes it easy to miss what the full course will actually cost.
cc measures the volume a solution occupies; mg measures the mass of the ingredient itself. In plain terms, a larger-looking solution volume does not mean more of the active ingredient was used. Ask about the solution volume and the product concentration separately — that is the only way to compare on equal terms.
- Product · SpecificationSpecific product name, content, and the meaning of the stated dose.
- Area · ScopeWhether it covers the entire face or specific areas such as around the eyes or cheeks.
- Total CostExpected number of sessions, whether anesthesia and VAT are included, and conditions for follow-up appointments and schedule changes.
Before your consultation, try writing down one concern, one desired change, and one burden you want to avoid. An explanation like “I’d like the depressions on my cheeks to be less visible, and I have a shoot in a week” is better for discussing goals and timing together than arriving with just a product name already decided.
The price per cc and the cost of the full plan are two different pieces of information. Write down the exact product, the area to be treated, and the expected number of sessions, then compare.
What Has Research Found?
The studies below reported changes in certain skin indicators, but they are not direct head-to-head comparison trials between Rejuran and Juvelook. Because the study populations and schedules differ, it is not possible to determine from this data alone which product shows faster or longer-lasting effects.
PN: A Study of 27 Participants Applied Around the Eyes
In a randomized, double-blind, split-face study, PN was injected on one side around the eye and non-cross-linked hyaluronic acid on the other side, three times at two-week intervals. Improvement rates for skin roughness, pore volume, and similar measures were higher on the PN side, but the difference between the two groups was not significant in the overall aesthetic improvement assessment. Results obtained around the eyes cannot be directly applied to the entire face or to all types of scarring.
PDLLA·HA: A Preliminary Study of 16 Participants Examining Skin Changes
In a PDLLA · non-cross-linked HA study, treatment was performed two to three times at four-week intervals. Changes in skin texture and fine lines were noted, and increases in collagen and elastic fibers were observed in biopsy samples. However, this was a small-scale preliminary study and did not directly compare results with PN. The treatment intervals and observation periods used in the study should not be read as individual prescriptions or as guaranteed maintenance periods.
Product Information and Adverse Event Data
Ingredient information was referenced from the Pharma Research Rejuran description and manufacturer product materials. PN and PDRN, and PDLLA and PLLA, are not the same terms respectively.
Case reports of nodules following PDLLA injection have also been published. Case reports are materials for understanding problems that can occur, and do not indicate the incidence across all patients. Reading both efficacy research and recovery and adverse effect information together makes the conditions for decision-making clearer.
Frequently Asked Questions
Q. If my skin is thin and sensitive, is Rejuran always the better fit?
Thin skin and sensitive skin should not be treated as the same condition. First, check for irritation or inflammation, which area is thin, and what you want to improve. Suitability is not determined by product name alone.
Q. Is Juvelook the only option effective for pores?
That cannot be stated categorically. Skin changes related to pores vary, and PN research also includes pore-related indicators. It is important to first distinguish whether your concern is pores, scarring, or skin texture.
Q. Can Rejuran also fill cheek hollowing?
The goal of addressing skin texture and fine lines is different from noticeable volume compensation. If hollowing is your primary concern, do not end with a consultation that only addresses skin condition — the location and extent of the volume deficit should be assessed separately.
Q. Is Juvelook Volume a higher-grade product than standard Juvelook?
Please do not understand it as a superior product that is better for every area. They are products with different content and application plans. You need to confirm the actual product based on whether you want to address skin texture or compensate for three-dimensional volume.
Q. If there is no visible effect the day after one session, does that mean it failed?
The day after treatment is too early to call it a failure. In the early period, swelling and the immediate effects of injection are mixed together. For skin texture and fine lines, it is better to compare progress at the checkpoint you agreed on before starting — using photos taken in the same lighting and with the same expression.
Q. If the next session is delayed due to scheduling, do I have to start over from the beginning?
Just because the schedule has changed does not automatically mean starting over from the beginning. The remaining plan is rebuilt based on the date and response of the previous treatment and your current condition. Do not arbitrarily shorten the interval to make up for missed sessions.
Q. Can nodules from Juvelook be resolved with a dissolving injection like for fillers?
Just because HA is present does not mean PDLLA can be removed by the same method. The product, location, and whether inflammation is present must all be confirmed before responding. If you feel something, do not try to press and break it up yourself — please have it checked through a medical consultation.
Q. Can treatment be received even when acne is active?
Active inflammation and the scarring from past acne are different issues. Whether it is possible to proceed with the planned treatment, including any areas with current inflammation, must first be assessed. Even if you scheduled an appointment for scar improvement, the plan may change depending on the skin condition on the day.
Q. If choosing only one of the two, what should be decided first?
Rather than ‘which product is more well-known,’ first decide ‘whether the thing I most want to change is fine lines, texture, or depressions.’ Listen to an explanation of how the recommended treatment connects to that goal, then compare the expected number of sessions and recovery needs — this will make choosing easier.